Abstract
Objectives: The objectives were 1) to explore the effect of hemoglobin F with obesity and gestational weight gain on heart period, respiratory sinus arrhythmia, oxy-hemoglobin, peripheral oxygenation, hemoglobin A1c , and systolic blood pressure, and 2) to determine if an association exists between the level of HbF and the frequency of perinatal events in low risk pregnant woman with varied body mass index (obese and not-obese).
Methods: An observational study of 41 pregnant women at three time points: 20, 28, and 36 weeks gestation. Data were organized according to the mean HbF level at 20 weeks gestation, with obesity (obese and non-obese), and gestational weight gain (using the Institute of Medicine's recommendation for weight gain). Repeated measures data were analyzed by the general linear model (GLM) to test for group differences and changes over time. Odds ratios were computed to compare the frequency of perinatal outcomes.
Results: There were significant changes in time for HP, RSA, and HbO2. Overall, HbO2 and SBP levels were higher and HP and RSA were lower in the obese women with the lower mean HbF category. Moreover, changes in time of HbO2 were different in obese and non-obese groups. Obese women with the lower mean HbF level had more frequent episodes of diabetes, wound dehiscence and giving birth by cesarean section or assistance with forceps or vacuum extraction. Non-obese women with lower mean HbF levels had postpartal bleeding.
Conclusion: The findings suggest that the pattern of change of HbF during pregnancy may be different for obese and non-obese women. However, further research is needed before HbF levels can be used as a marker for altered adaptation in pregnancy.
Sigma Membership
Unknown
Type
Presentation
Format Type
Text-based Document
Study Design/Type
Observational
Research Approach
N/A
Keywords:
Vagal Response, Hemoglobin F, Adaptation to Pregnancy
Recommended Citation
Helmreich, Rebecca Jo, "Hemoglobin F impacts physiologic variables and perinatal events" (2012). Convention. 47.
https://www.sigmarepository.org/convention/2011/presentations_2011/47
Conference Name
41st Biennial Convention
Conference Host
Sigma Theta Tau International
Conference Location
Grapevine, Texas, USA
Conference Year
2011
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Acquisition
Proxy-submission
Hemoglobin F impacts physiologic variables and perinatal events
Grapevine, Texas, USA
Objectives: The objectives were 1) to explore the effect of hemoglobin F with obesity and gestational weight gain on heart period, respiratory sinus arrhythmia, oxy-hemoglobin, peripheral oxygenation, hemoglobin A1c , and systolic blood pressure, and 2) to determine if an association exists between the level of HbF and the frequency of perinatal events in low risk pregnant woman with varied body mass index (obese and not-obese).
Methods: An observational study of 41 pregnant women at three time points: 20, 28, and 36 weeks gestation. Data were organized according to the mean HbF level at 20 weeks gestation, with obesity (obese and non-obese), and gestational weight gain (using the Institute of Medicine's recommendation for weight gain). Repeated measures data were analyzed by the general linear model (GLM) to test for group differences and changes over time. Odds ratios were computed to compare the frequency of perinatal outcomes.
Results: There were significant changes in time for HP, RSA, and HbO2. Overall, HbO2 and SBP levels were higher and HP and RSA were lower in the obese women with the lower mean HbF category. Moreover, changes in time of HbO2 were different in obese and non-obese groups. Obese women with the lower mean HbF level had more frequent episodes of diabetes, wound dehiscence and giving birth by cesarean section or assistance with forceps or vacuum extraction. Non-obese women with lower mean HbF levels had postpartal bleeding.
Conclusion: The findings suggest that the pattern of change of HbF during pregnancy may be different for obese and non-obese women. However, further research is needed before HbF levels can be used as a marker for altered adaptation in pregnancy.
Description
41st Biennial Convention - 29 October-2 November 2011. Theme: People and Knowledge: Connecting for Global Health. Held at the Gaylord Texan Resort & convention Center.