Abstract
Session presented on Monday, November 9, 2015 and Tuesday, November 10, 2015:
The purpose of this study is to disseminate current evidence on Methylenetetrahydrofolate reductase (MTHFR) gene mutations in children and their parents, and related epigenetic factors in the prevention of the children's congenital heart defects (CHD), through meta-analyses. MTHFR gene plays an important role in the methylation pathway for health and wellbeing across generations in the development of CHD. The association between the polymorphisms of MTHFR and CHD is contentious, thus we conducted meta-analyses on MTHFR gene mutations and related epigenetic factors across generations in the development of CHD. Quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Preliminary results included 4039 cases and 6849 controls from 31 studies for children, 817 cases and 836 controls from 16 studies for mothers, as well as 246 cases and 300 controls from 6 studies for fathers, of children with CHD. Based on children's and their parents' genotypes, MTHFR 677 TT homozygous mutation type was associated with increased risk (p < 0.05), whereas 677 CC wild genotype was protective for children from CHD (p < 0.05). Maternal folate supplementation during preconception and gestation was associated with a decreased risk of CHD (RR = 0.60, p < 0.01, 5 studies, 761 cases and 1428 controls). On the other hand, no supplementation of folate during preconception and gestation for mothers was associated with an increased risk of CHD (RR=1.26, p < 0.05). Maternal smoking was potentially associated with the development of CHD (3 studies, 799 cases and 1113 controls, RR =1.156, p = 0.053). Future studies are needed to examine epigenetic factors associated with MTHFR gene variations in the prevention of CHD across generations.
Sigma Membership
Iota Sigma
Type
Poster
Format Type
Text-based Document
Study Design/Type
N/A
Research Approach
N/A
Keywords:
Congenital Heart Defects, Epigenetics, Meta-Analyses
Recommended Citation
Yang, Hsiao-Ling and Shiao, Shyang-Yun Pamela K., "Meta-analyses of epigenetic factors in the prevention of congenital heart defects: MTHFR C677T human gene variations across generations from parents to children" (2016). Convention. 196.
https://www.sigmarepository.org/convention/2015/posters_2015/196
Conference Name
43rd Biennial Convention
Conference Host
Sigma Theta Tau International
Conference Location
Las Vegas, Nevada, USA
Conference Year
2015
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
Abstract Review Only: Reviewed by Event Host
Acquisition
Proxy-submission
Meta-analyses of epigenetic factors in the prevention of congenital heart defects: MTHFR C677T human gene variations across generations from parents to children
Las Vegas, Nevada, USA
Session presented on Monday, November 9, 2015 and Tuesday, November 10, 2015:
The purpose of this study is to disseminate current evidence on Methylenetetrahydrofolate reductase (MTHFR) gene mutations in children and their parents, and related epigenetic factors in the prevention of the children's congenital heart defects (CHD), through meta-analyses. MTHFR gene plays an important role in the methylation pathway for health and wellbeing across generations in the development of CHD. The association between the polymorphisms of MTHFR and CHD is contentious, thus we conducted meta-analyses on MTHFR gene mutations and related epigenetic factors across generations in the development of CHD. Quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Preliminary results included 4039 cases and 6849 controls from 31 studies for children, 817 cases and 836 controls from 16 studies for mothers, as well as 246 cases and 300 controls from 6 studies for fathers, of children with CHD. Based on children's and their parents' genotypes, MTHFR 677 TT homozygous mutation type was associated with increased risk (p < 0.05), whereas 677 CC wild genotype was protective for children from CHD (p < 0.05). Maternal folate supplementation during preconception and gestation was associated with a decreased risk of CHD (RR = 0.60, p < 0.01, 5 studies, 761 cases and 1428 controls). On the other hand, no supplementation of folate during preconception and gestation for mothers was associated with an increased risk of CHD (RR=1.26, p < 0.05). Maternal smoking was potentially associated with the development of CHD (3 studies, 799 cases and 1113 controls, RR =1.156, p = 0.053). Future studies are needed to examine epigenetic factors associated with MTHFR gene variations in the prevention of CHD across generations.
Description
43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.