Abstract
Session presented on Monday, November 9, 2015 and Tuesday, November 10, 2015:
Tryptophan, an essential amino acid, serves as a precursor to serotonin synthesis with the rate of synthesis dependent on tryptophan concentrations in the brain (Fernstrom, 2013). Because serotonin is involved in the regulation of mood, low brain serotonin levels may contribute to increased depression. However, tryptophan is obtained through the diet because it cannot be synthesized by the body (Soh & Walter, 2011). Therefore, some have questioned if dietary consumption of tryptophan can affect behavior in depressed, vulnerable individuals. Sleep has also been implicated to have a relationship with tryptophan which may in turn have an effect on levels of depression. Therefore, the purpose of this study is to examine the effects of dietary tryptophan on sleep, depression, and mood in a population of depressed participants. Based on Pender's Health Promotion Model and using a randomized crossover study design, 36 participants with depression will be examined for differences in sleep, depression, and mood after consuming a high tryptophan diet, a low tryptophan diet and a control diet for a week each. The order of the sessions will be counterbalanced across the control and dietary treatment groups. A two-week washout period is planned between the diets. Study measures will include Demographics, weighed Tryptophan food Intakes, the Positive and Negative Affect Schedule, Zung's Self-Rating Depression Scale, the Sternberg Item Recognition Test, the Actiwatch Sleep Watch, and Serotonin and Cortisol Laboratory tests. A repeated measures ANOVA will be used to calculate differences between sleep, depression, and mood scores resulting from the consumption of the two tryptophan diets and the control diet. Further post hoc analysis of significant results will follow. Benefits of this study include determining whether ingestion of functional foods, such as high tryptophan foods, may provide significant mental and physiologic benefits to vulnerable depressed individuals. The impact of these results may have a positive effectfor the general population as well.
Sigma Membership
Eta Upsilon
Type
Poster
Format Type
Text-based Document
Study Design/Type
N/A
Research Approach
N/A
Keywords:
Sleep, Tryptophan, Depression
Recommended Citation
Lindseth, Glenda and Petros, Thomas, "The neurobehavioral effects of consuming dietary tryptophan" (2016). Convention. 215.
https://www.sigmarepository.org/convention/2015/posters_2015/215
Conference Name
43rd Biennial Convention
Conference Host
Sigma Theta Tau International
Conference Location
Las Vegas, Nevada, USA
Conference Year
2015
Rights Holder
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Acquisition
Proxy-submission
The neurobehavioral effects of consuming dietary tryptophan
Las Vegas, Nevada, USA
Session presented on Monday, November 9, 2015 and Tuesday, November 10, 2015:
Tryptophan, an essential amino acid, serves as a precursor to serotonin synthesis with the rate of synthesis dependent on tryptophan concentrations in the brain (Fernstrom, 2013). Because serotonin is involved in the regulation of mood, low brain serotonin levels may contribute to increased depression. However, tryptophan is obtained through the diet because it cannot be synthesized by the body (Soh & Walter, 2011). Therefore, some have questioned if dietary consumption of tryptophan can affect behavior in depressed, vulnerable individuals. Sleep has also been implicated to have a relationship with tryptophan which may in turn have an effect on levels of depression. Therefore, the purpose of this study is to examine the effects of dietary tryptophan on sleep, depression, and mood in a population of depressed participants. Based on Pender's Health Promotion Model and using a randomized crossover study design, 36 participants with depression will be examined for differences in sleep, depression, and mood after consuming a high tryptophan diet, a low tryptophan diet and a control diet for a week each. The order of the sessions will be counterbalanced across the control and dietary treatment groups. A two-week washout period is planned between the diets. Study measures will include Demographics, weighed Tryptophan food Intakes, the Positive and Negative Affect Schedule, Zung's Self-Rating Depression Scale, the Sternberg Item Recognition Test, the Actiwatch Sleep Watch, and Serotonin and Cortisol Laboratory tests. A repeated measures ANOVA will be used to calculate differences between sleep, depression, and mood scores resulting from the consumption of the two tryptophan diets and the control diet. Further post hoc analysis of significant results will follow. Benefits of this study include determining whether ingestion of functional foods, such as high tryptophan foods, may provide significant mental and physiologic benefits to vulnerable depressed individuals. The impact of these results may have a positive effectfor the general population as well.
Description
43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.