Abstract
Pharmacogenetic testing has the potential to improve pain management through addressing wide interindividual variations in responses to pharmacogenetically actionable opioids, ultimately decreasing costly adverse drug effects and improving responses to these medications. A recent review of pharmacogenomics in the nursing literature highlighted the need for nurses to more fully embrace the burgeoning field of pharmacogenomics in nursing research, clinical practice, and education. Despite the promise of pharmacogenetic testing, significant challenges exist for evaluating outcomes related to its implementation, including oversimplification of medication exposure, the complexity of patients' clinical profiles, and the characteristics of healthcare contexts in which medications are prescribed. A better understanding of these challenges could enhance the assessment and documentation of the benefits of pharmacogenetic testing in guiding opioid therapies. This dissertation is intended to address the challenges of evaluating outcomes of pharmacogenetic testing implementation and the need for nurses to lead pharmacogenomic-related research. The dissertation purpose was to advance the sciences of nursing, pain management, and pharmacogenomics through the development of a typology of common patterns of medication exposure to known pharmacogenetically actionable opioids (codeine & tramadol).
Sigma Membership
Beta Epsilon
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Qualitative Research
Keywords:
Clinical Implementation, Pain Management, Pharmacogenomics
Advisor
Janet S. Carpenter
Second Advisor
Claire B. Draucker
Third Advisor
Marion E. Broome
Fourth Advisor
Ann M. Holmes
Degree
PhD
Degree Grantor
Indiana University
Degree Year
2016
Recommended Citation
Knisely, Mitchell R., "Understanding exposure to pharmacogenetically actionable opioids in primary care" (2021). Dissertations. 1002.
https://www.sigmarepository.org/dissertations/1002
Rights Holder
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All permission requests should be directed accordingly and not to the Sigma Repository.
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Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2021-11-19
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 10133761; ProQuest document ID: 1810727750. The author still retains copyright.