Abstract
Thermal injury induces a profound inflammatory response, which is manifested locally and systemically. Pain is an integral part of this response. However, little is known about the mechanisms of burn injury pain. Clinically, pain behaviors suggest that both acute and chronic pain mechanisms are induced following thermal injury. However, mechanisms of pain following thermal injury have not received the attention it deserves. To be sure, the models and laboratory assays necessary to tease apart the complex mechanisms that contribute to burn pain have not been well developed. However, understanding the molecular events that occur in cells subjected to noxious heat is critical to the advance the development of therapeutic targets for analgesic therapies following thermal injury. This dissertation establishes a program of research to investigate the mechanisms of pain following thermal injury.
Sigma Membership
Nu Xi at-Large
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Other
Keywords:
Burns, Hyperalgesia, Burn Care
Advisor
Kathleen A. Puntillo
Second Advisor
Christine Miaskowski
Third Advisor
Jon Levine
Degree
PhD
Degree Grantor
University of California, San Francisco
Degree Year
2005
Recommended Citation
Summer, Gretchen J., "Mechanisms of pain following thermal injury" (2023). Dissertations. 1053.
https://www.sigmarepository.org/dissertations/1053
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2023-03-24
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3179964; ProQuest document ID: 305007128. The author still retains copyright.