Abstract

Pro-inflammatory cytokines, especially Interleukin (IL)-6, are elevated in the brains and serum of very premature infants in association with perinatal infectious and hypoxic/ischemic insults. To determine potential adverse effects of IL-6 on brain development, cross-fostered litters of male cd-1 mice were injected sub-cranially with hyper-IL-6 or vehicle at postnatal day (PND) 4 and examined for alterations in functional landmarks of CNS development.

Description

This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3070827; ProQuest document ID: 305565387. The author still retains copyright.

Susan Brunssen

Author Details

Susan Brunssen, PhD, RN

Sigma Membership

Alpha Alpha

Type

Dissertation

Format Type

Text-based Document

Study Design/Type

Other

Research Approach

Quantitative Research

Keywords:

Inflammation in Infants, Health Problems in Premature Babies, Hyperactivity

Advisor

Diane Holditch-Davis

Second Advisor

Jean G. Harry

Degree

PhD

Degree Grantor

The University of North Carolina at Chapel Hill

Degree Year

2002

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.

All permission requests should be directed accordingly and not to the Sigma Repository.

All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Proxy-submission

Date of Issue

2020-06-19

Full Text of Presentation

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