Abstract

Increased cerebral spinal fluid (CSF) concentrations of stress mediators, such as corticotropin releasing factor (CRF), norepinephrine (NE) and Substance P (Sp) have been reported to be abnormal in several stress-related syndromes (post-traumatic stress disorder, depression, fibromyalgia) which frequently co-exist with irritable bowel syndrome (IBS).

To determine if CSF levels of CRF, NE and SP differ between IBS and healthy controls and if CSF levels correlate with peripheral measures of HPA axis regulation and clinical parameters.

Description

This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3110815; ProQuest document ID: 305350339. The author still retains copyright.

Author Details

Leah Z. Fitzgerald, PhD, FNP-BC

Sigma Membership

Gamma Tau at-Large

Type

Dissertation

Format Type

Text-based Document

Study Design/Type

Randomized Controlled Trial

Research Approach

Qualitative Research

Keywords:

Stress Reactions to Health, Anxiety and Chronic Illness, Neurotransmitters and Disease

Advisor

Donna L. Vredevoe

Degree

PhD

Degree Grantor

University of California, Los Angeles

Degree Year

2003

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.

All permission requests should be directed accordingly and not to the Sigma Repository.

All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Proxy-submission

Date of Issue

2020-08-07

Full Text of Presentation

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