Abstract
Recent studies suggest that standard dose chemotherapy (CTX) may cross the blood-brain barrier. However, the evidence for CTX-induced cognitive impairments in breast cancer patients is inconsistent.
Purposes. (1) to describe the literature about CTX-induced cognitive impairments in women with breast cancer; (2) to review the domains of cognitive function and their corresponding neuroanatomic structures as well as present current evidence for neurotoxicity associated with specific CTX agents and potential mechanisms for CTX-induced cognitive impairments; (3) to estimate the effect sizes for the effect of CTX on each domain of cognitive function; (4) to determine the sensitivity of neuropsychological tests which have been used to evaluate CTX-induced impairment in various domains of cognitive function in breast cancer patients; and (5) to assess changes in cognitive function over time in breast cancer patients receiving CTX, and evaluate potential relationships between cognitive function and anxiety, depression, fatigue, hemoglobin levels, menopausal status, and perceived cognitive function.
Sigma Membership
Alpha Eta
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Quantitative Research
Keywords:
Memory Impairment, Breast Cancer, Treatment Side-effects
Advisor
Marilyn J. Dodd
Degree
PhD
Degree Grantor
University of California, San Francisco
Degree Year
2007
Recommended Citation
Jansen, Catherine E., "Cognitive function in breast cancer patients undergoing chemotherapy" (2019). Dissertations. 1339.
https://www.sigmarepository.org/dissertations/1339
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2019-04-10
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3261235; ProQuest document ID: 304878866. The author still retains copyright.