Abstract
Statement of the Problem. Obstructive sleep apnea (OSA) initiates hypoxemia and elevated inflammatory markers, events which contribute to vaso-occlusion in sickle cell disease (SCD) independent of OSA. Children with SCD are at increased risk of developing OSA due to SCD-related adenotonsillar hypertrophy, and OSA may increase vaso-occlusion and SCD severity through hypoxemia and inflammation. Identification of OSA-related factors influencing SCD severity is important to reduce SCD-related complications. Purpose. The purpose of this study was to test the hypotheses that SCD severity is associated with OSA, is associated with OSA-related changes in polysomnography parameters and treatment of OSA with adenotonsillectomy decreases SCD severity. Methods: A case series study was conducted collecting data from the medical record. Subjects were children aged 2-18 years with SCD, referred to a sleep laboratory for evaluation of OSA.
Sigma Membership
Pi at-Large
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Case Study/Series
Research Approach
Pilot/Exploratory Study
Keywords:
Sickle Cell Disease, Effects of Poor Sleep, Compounding Factors
Advisor
Jeanne Geiger-Brown
Degree
PhD
Degree Grantor
University of Maryland, Baltimore
Degree Year
2009
Recommended Citation
Rogers, Valerie E., "Relationship of obstructive sleep apnea and sickle cell disease severity in children" (2020). Dissertations. 1410.
https://www.sigmarepository.org/dissertations/1410
Rights Holder
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All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2020-02-04
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3355104; ProQuest document ID: 305064371. The author still retains copyright.