Abstract
The principal toxicity for children who receive vincristine for the treatment of acute lymphocytic leukemia (ALL) is peripheral neuropathy, with symptoms that negatively affect physical function and may require the reduction or withdrawal of chemotherapy; even though cumulative dosing has not been shown to increase peripheral neuropathy. This population not only has to deal with the physical challenges of cancer but also can have psychosocial and cognitive effects from treatment. Utilizing secondary analysis, the purpose of this dissertation is to examine peripheral neuropathy (PN) trajectory during the second year of ALL treatment which has not been investigated in children receiving vincristine. Describing these symptom patterns in children carries the potential to guide future targeted nursing interventions. The Symptom Management Model will conceptually guide this three-manuscript dissertation to describe the patients' experience and the development of PN over year two of treatment.
Sigma Membership
Rho
Lead Author Affiliation
University of Michigan, Ann Arbor, Michigan, USA
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Other
Keywords:
Acute Lymphocytic Leukemia, Children, Vincristine, Physical Function
Advisor
Gwen Wyatt
Second Advisor
Barb Given
Third Advisor
Rebecca Lehto
Degree
PhD
Degree Grantor
Michigan State University
Degree Year
2020
Recommended Citation
Lee, Deborah R., "Evalution of peripheral neuropathy among childhood cancer patients" (2022). Dissertations. 1550.
https://www.sigmarepository.org/dissertations/1550
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2022-11-01
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 28002373; ProQuest document ID: 2425903743. The author still retains copyright.