Abstract

Oxaliplatin-induced peripheral neuropathy (OIPN) occurs in 85-95% of patients receiving FOLFOX or FOLFIRINOX, oxaliplatin-based chemotherapy for invasive gastrointestinal (GI) cancers. Persistent OIPN can impair long-term quality of life (QOL). No OIPN cures are known. Aerobic physical activity (PA) may reduce OIPN by enhancing circulation and re-distributing neurotoxic oxaliplatin away from vulnerable neurons. However, no trials have evaluated solely aerobic exercise for OIPN. This dissertation reports the results of a 1) literature review on exercise for chemotherapy-induced peripheral neuropathy, and 2) pilot randomized controlled trial (RCT) of brisk walking for OIPN in FOLFOX/FOLFIRINOX-receiving GI cancer survivors. The "MI-Walk Intervention" - an eight-week motivational enhancement therapy (MET)- home-based aerobic walking intervention - was tested in this study.

Description

This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 28006510; ProQuest document ID: 2405588447. The author still retains copyright.

Author Details

Grace A. Kanzawa-Lee, PhD, BSN, RN

Sigma Membership

Rho

Type

Dissertation

Format Type

Text-based Document

Study Design/Type

Other

Research Approach

Pilot/Exploratory Study

Keywords:

Cancer, Chemotherapy, Neurotoxicity, Peripheral Neuropathy, Survivorship

Advisor

Ellen M. Lavoie Smith

Second Advisor

Kenneth Resnicow

Third Advisor

Janet Louise Larson

Fourth Advisor

Robert Ploutz-Snyder

Degree

PhD

Degree Grantor

University of Michigan

Degree Year

2020

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.

All permission requests should be directed accordingly and not to the Sigma Repository.

All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Proxy-submission

Date of Issue

2021-08-09

Full Text of Presentation

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