Abstract
CA125, a tumor-associated antigen, is primarily used to monitor epithelial ovarian cancer. However, CA125 alone lacks the sensitivity and specificity necessary for population-based screening in healthy women. Barriers to the development of a screening assay includes the low incidence of the disease, large inter-individual variability in CA125 levels, fluctuations in levels during the phases of the menstrual cycle (i.e., menses, follicular, luteal), ethnicity, menopausal status, and other benign conditions. Evaluation of the molecular species of serum CA125 is a vital step in understanding the underlying biology of CA125. The specific aims of this study, in a sample of healthy women were: (1) To determine if the molecular species of CA125 differ across the three phases of the menstrual cycle; and (2) To determine if the absolute serum concentrations of CA125 differ across the three phases of the menstrual cycle, using two common commercial CA125 assays.
Sigma Membership
Alpha Eta
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Descriptive/Correlational
Research Approach
Quantitative Research
Keywords:
Cancer Screenings, Ovarian Cancer Testing, Oncology Nursing
Advisor
Bradley E. Aouizerat
Second Advisor
Christine Miaskowski
Degree
PhD
Degree Grantor
University of California, San Francisco
Degree Year
2010
Recommended Citation
McLemore, Monica Rose, "An evaluation of the molecular species of CA125 across the three phases of the menstrual cycle" (2020). Dissertations. 878.
https://www.sigmarepository.org/dissertations/878
Rights Holder
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Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2020-04-15
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3438961; ProQuest document ID: 849722376. The author still retains copyright.