Abstract
Group B Streptococcus (GBS) is a leading cause of neonatal morbidity and mortality. The current prevention strategy involves universal antenatal screening for GBS and IV intrapartum antibiotic prophylaxis (IAP) for those who test positive. Despite this approach, up to 80% of cases of early onset GBS neonatal disease are in infants born to birth givers who screened negative for GBS, which can be described as residual GBS.
Probiotics are a primary prevention strategy for antenatal GBS. This was a substudy of a randomized, double-blind, placebo-controlled trial. Participants in the parent study were randomized to probiotics verses placebo and the major outcome was GBS colonization at 36 weeks' gestation. The purpose of this exploratory sub-study was to determine the effect of antepartum exposure to probiotic (Florajen3) versus placebo on maternal and neonatal residual GBS at the time of admission to the hospital for labor and birth. The hypotheses were: compared to the placebo group (a) More participants in the probiotics group will test negative for GBS on intrapartum vaginal/rectal swabs (b) Fewer neonates born to birth givers in the probiotic group will have GBS on oral/nasopharynx cultures taken post-birth.
Sigma Membership
Theta Tau
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Other
Keywords:
Childbirth, Infections, Antenatal Care
Advisor
Lisa Hanson
Second Advisor
Leona VandeVusse
Third Advisor
Karen Robinson
Degree
PhD
Degree Grantor
Marquette University
Degree Year
2022
Recommended Citation
Malloy, Emily M., "The efficacy of an antenatal probiotic intervention to reduce residual group B Streptococcus" (2023). Dissertations. 974.
https://www.sigmarepository.org/dissertations/974
Rights Holder
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All permission requests should be directed accordingly and not to the Sigma Repository.
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Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2023-04-07
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 29069452; ProQuest document ID: 2656860201. The author still retains copyright.