70% ethanol for decontamination of central venous lines exposed to calcineurin inhibitors

Abstract

Tacrolimus, commonly used for GvHD prophylaxis is usually administered via a dedicated CVL and trough levels drawn from the unexposed lumen. Being an oil-based medication, it may be adsorbed to the inside lumen of the CVL and result in falsely high levels drawn from an inadvertently exposed lumen. There is no treatment for decontamination of such CVLs and natural decay occurs over months before the CVL can be used to draw reliable trough levels.

Description

Disseminating this report in an open-access repository does not violate the policies and rights of the journal.

Notes

The information contained in this report formed the basis of a manuscript published as the following: Copacia, J. A., Taylor, K., Laudick, M., Abu-Arja, R., Auletta, J. J., Rangarajan, H. G., … Bajwa, R. (2013). 70% Ethanol for Decontamination of Cvl Exposed to Calcineurine Inhibitors. Biology of Blood and Marrow Transplanatation, 22(3), S287. doi: http://dx.doi.org/10.1016/j.bbmt.2015.11.739

Authors

Jessica Ann CopaciaFollow
Kimberly Taylor
Melissa Laudick
Rolla Abu-Arja
Jeffery J. Auletta
Hemalatha G. Rangarajan
Amy Pyle-Eilola
Joseph Stanek
Vinta B. Pai
Rajinder Bajwa

Author Details

Jessica Ann Copacia, APN; Kimberly Taylor, APN; Melissa Laudick, APN; Rolla Abu-Arja, MD; Jeffery J. Auletta, MD; Hemalatha G. Rangarajan, MD; Amy Pyle-Eilola, PhD; Joseph Stanek, MS; Vinita B Pai, Pharm D, MS; Rajinder Bajwa, MBBS, MRCP, MD

Sigma Membership

Non-member

Type

Research Study

Format Type

Text-based Document

Study Design/Type

Other

Research Approach

Quantitative Research

Keywords:

Calcineurin Inhibitor, Tacrolimus, Ethanol, Lock Therapy, Graft Versus Host Disease

Recommended Citation

Copacia, Jessica Ann; Taylor, Kimberly; Laudick, Melissa; Abu-Arja, Rolla; Auletta, Jeffery J.; Rangarajan, Hemalatha G.; Pyle-Eilola, Amy; Stanek, Joseph; Pai, Vinta B.; and Bajwa, Rajinder, "70% ethanol for decontamination of central venous lines exposed to calcineurin inhibitors" (2024). General Submissions: Clinical Settings Materials. 21.
https://www.sigmarepository.org/gen_sub_csm/21

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All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

Peer-review: Single Blind

Acquisition

Self-submission

Full Text of Presentation

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