Abstract
This work will extend the current approach in the field and has the potential to decode the etiopathogenesis of schizophrenia by focusing on symptom domains which not only have important and direct clinical outcomes but that are refractory to existing treatments. Utilizing advances in statistical and bioinformatic methods this study proposes to examine the functional mechanisms of psychotic and schizophrenia symptoms in the developmental period in a sample of youth and in patients diagnosed with schizophrenia.
Sigma Membership
Alpha Alpha
Lead Author Affiliation
The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Type
Report
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Quantitative Research
Keywords:
Schizophrenia, Treatment Resistance, Polygenic Risk Scores
Recommended Citation
Xavier, Rose Mary; Britt, Brian M.; Farrell, Martilias; Harner, Matthew K.; Deittrich, Tyler E.; Filmyer, Dawn M.; Bruno, Lisa M.; Bur, Raquel E.; Almasy, Laura; Sullivan, Patrick F.; and Josiassen, Richard, "Polygenic risk score distributions suggest that treatment resistance in schizophrenia is unlikely to be driven by schizophrenia associated common variations" (2021). Sigma Foundation for Nursing Research Grant Reports. 1.
https://www.sigmarepository.org/grant_reports/1
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
None: Sigma Grant Recipient Report
Acquisition
Self-submission
Date of Issue
2021-08-18
Full Text of Presentation
wf_yes
Description
Rose Mary Xavier, PhD, MS, RN, PMHNP-BC was the recipient of the Sigma/Western Institute of Nursing Research Grant, 2018-2019 cohort. Additional funding information: NIMH K01 MH108894