Abstract
The purpose of this project was to address the convergent effect of POE and PAE on key placental immune and serotonin factors. The central hypothesis was that increased opioid-induced activation of the TLR4 pathway in the placenta results in dysregulated immune cytokine expression and serotonin function and this relationship will be magnified in POE and PAE placental tissue.
Sigma Membership
Gamma Sigma
Lead Author Affiliation
The University of New Mexico, Albuquerque, New Mexico, USA
Type
Report
Format Type
Text-based Document
Study Design/Type
Descriptive/Correlational
Research Approach
Quantitative Research
Keywords:
Opioids, Alcohol, Placental Immune Factors, Serotonin Factors, Dsyregulated Immune Cytokine Expression
Recommended Citation
Ruyak, Sharon; Noor, Shahani; Sun, Melody; Oropeza, Annette Fernandez; DiDomenico, Jared; Rodriquez, Dominique; Marquez, Lidia Enriquez; Bakhireva, Ludmila; and Milligan, Erin, "Evidence for human placental SLC6A4 dysregulation in prenatal opioid and alcohol exposure" (2022). Sigma Foundation for Nursing Research Grant Reports. 104.
https://www.sigmarepository.org/grant_reports/104
Rights Holder
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Review Type
None: Sigma Grant Recipient Report
Acquisition
Proxy-submission
Date of Issue
2022-02-16
Full Text of Presentation
wf_yes
Description
Dr. Ruyak was the recipient of a Sigma Foundation for Nursing Research Grant.