Abstract

Aims and objectives: The aim of this integrative review is to provide a practice recommendation for the administration of dexmedetomidine versus midazolam in the pediatric population prior to undergoing anesthesia. Methods: Articles published from 2011-2018 were critically evaluated for their validity, reliability, and rigor of study. Articles were selected based on study designs and methods that assisted in answering the guided research questions. Results: The efficacy of preoperative dexmedetomidine and midazolam were compared in pediatrics. The initial search using keywords yielded 163 articles. Articles were chosen based on their relevance. Common variables within studies were chosen to examine and data was recorded. Data was considered statistically significant if p-value was less than 0.05. Implications for practice: Practice implications encourage the use of both dexmedetomidine and midazolam as premedication in pediatrics. Premedication should only be administered in the pediatric population when adequate monitoring is available and there are no contraindications noted. Dexmedetomidine was found to have a statistically significant decrease in blood pressure and/or heart rate. However, there was never a need to treat vital signs and patients were considered stable hemodynamically. Conclusion: A conclusion cannot be made from this integrative review whether dexmedetomidine or midazolam is superior. Current literature comparing dexmedetomidine and midazolam has shown statistically significant results. Dexmedetomidine was shown in more than half of the studies to have a deeper sedation, better mask acceptance, and better separation from parents.

Megan Gangwish

Author Details

Megan Gangwish, DNAP, RN, SRNA

Sigma Membership

Non-member

Type

Other Graduate Paper

Format Type

Text-based Document

Study Design/Type

Integrative Review

Research Approach

Other

Keywords:

dexmedetomidine, precedex, midazolam, versed, pediatric, premedication, anesthesia

Advisor

Chandler, Holly

Degree

Doctoral-Other

Degree Grantor

Bryan College of Health Sciences

Degree Year

2020

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Review Type

Faculty Approved: Degree-based Submission

Acquisition

Proxy-submission

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