Abstract

The purpose of this integrative review is to investigate the potential receptors of cannabidiol (CBD) in order to better understand any potential clinical implication(s) during administration of anesthesia and analgesia. A total of eight full-text review articles were included from multiple databases. All eight of the review articles were analyzed for evidence related to the target receptors of CBD. Analysis of the review articles focused on potential receptors and implications of CBD as it relates to anesthesia and analgesia. Two primary receptors were discovered, 5-HT1A and TRPV1. In total, 14 potential receptors of CBD have been identified resulting in multiple possible clinical uses. The potential clinical uses of CBD identified were for pain relief, as an anti-inflammatory and antiarrhythmic, treating anxiety, and having anticonvulsant properties. Currently research in human subjects is lacking along with minimal to no federal regulation of CBD. For CBD to be clinically impactful, there needs to be research done in human subjects. Federal regulations are needed to improve safety and quality of CBD. Specifically, further research related to individual interactions with common drugs used in anesthesia and the long-term effects of CBD use is necessary.

Author Details

Teran A. Walford, DNAP, CRNA

Sigma Membership

Non-member

Type

DNP Capstone Project

Format Type

Text-based Document

Study Design/Type

Other

Research Approach

Translational Research/Evidence-based Practice

Keywords:

Cannabidiol, CBD, Receptors, Anesthesia Interactions

Advisor

Hadenfeldt, Sharon

Degree

Doctoral-Other

Degree Grantor

Bryan College of Health Sciences

Degree Year

2022

Rights Holder

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All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

Faculty Approved: Degree-based Submission

Acquisition

Proxy-submission

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