Abstract

Objective: The object of this integrative review was to investigate the analgesic benefit and side effect profile of the coadministration of ketamine and magnesium. Secondary goals were to provide an evidence-based recommendation on the ideal dosing, frequency, and order of administration of the medications. Methods: Relevant articles published between January 2001 and May 2019 were examined for quality, strength, and generalizability. Results: Beginning evidence suggests ketamine may interact with magnesium to provide synergistic NMDA receptor antagonism and analgesia. Evidence from animal studies proposes that order of administration may influence potency, with ketamine prior to magnesium producing better analgesia. Coadministration of ketamine and magnesium in low doses intended for analgesia did not result in a significant increase in side effects in these studies. While stronger evidence is needed, the coadministration of ketamine and magnesium may provide synergistic analgesic benefit without an increase in side effects.

Author Details

Lauren Chiavetta, DNAP, CRNA

Sigma Membership

Non-member

Type

Other Graduate Paper

Format Type

Text-based Document

Study Design/Type

Other

Research Approach

Translational Research/Evidence-based Practice

Keywords:

Ketamine, Magnesium, Coadministration, Synergism, Analgesia

Advisor

Pecka, Shannon

Degree

Doctoral-Other

Degree Grantor

Bryan College of Health Sciences

Degree Year

2020

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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Review Type

Faculty Approved: Degree-based Submission

Acquisition

Proxy-submission

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