Abstract
Session presented on: Tuesday, July 23, 2013:
Purpose: Systematically review clinical trials of Traditional East Asian Medicine, herbals, soy and isoflavone preparations, and body-mind therapies for managing symptoms of hot flashes and at least one additional symptom, including mood, sleep, pain, and cognitive symptoms.
Methods: Searched PubMED/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for randomized controlled trials reported in English between 2004 and 2012. Of 1193 abstracts identified, 59 trials included data on hot flash and at least one other symptom.
Results: Several trials of acupuncture (13), herbals including black cohosh (18), soy and isoflavone preparations (17), and body-mind therapies (9) yielded significant effects on multiple symptoms. Seven acupuncture trials revealed significantly reduced hot flash frequency, intensity or bother, along with improved mood and sleep. Chinese herbal medicine significantly reduced HF frequency, and mood, sleep, and pain. Four of 9 black cohosh trials significantly improved hot flashes, sleep and mood. Two trials of at least 60-70 mg of isoflavones daily significantly reduced vasomotor, sleep, cognitive and pain symptoms. Equol supplements of 30 mg/d for non-Equol producing women significantly reduced vasomotor, psychological and somatic symptoms. Two trials of Genistein preparations reduced hot flashes by 30-51% but not other symptoms. Red Clover isoflavone (80 mg/d) significantly reduced hot flashes, night sweats, sleep, cognition and pain symptoms. Mindfulness and relaxation therapy significantly reduced hot flashes and sleep symptoms. Yoga significantly reduced hot flashes and improved cognitive symptoms. Exercise trials yielded mixed results, with half significantly reducing hot flashes and one cognitive symptoms.
Conclusion: Few investigators report treatment effects in ways that allow clinicians to consider symptom clusters when prescribing therapies, despite promising therapies
Sigma Membership
Unknown
Type
Presentation
Format Type
Text-based Document
Study Design/Type
Systematic Review
Research Approach
N/A
Keywords:
Menopause, Symptom Clusters, Complementary Therapies
Recommended Citation
Woods, Nancy Fugate; Thomas, Annette; Mitchell, Ellen Sullivan; Schnall, Janet; Taylor-Swanson, Lisa; Ismail, Rita; and Cray, Lori, "Toward therapeutics for symptom clusters during the menopausal transition and early postmenopause: A systematic review" (2013). INRC (Congress). 230.
https://www.sigmarepository.org/inrc/2013/presentations_2013/230
Conference Name
24th International Nursing Research Congress
Conference Host
Sigma Theta Tau International
Conference Location
Prague, Czech Republic
Conference Year
2013
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Acquisition
Proxy-submission
Toward therapeutics for symptom clusters during the menopausal transition and early postmenopause: A systematic review
Prague, Czech Republic
Session presented on: Tuesday, July 23, 2013:
Purpose: Systematically review clinical trials of Traditional East Asian Medicine, herbals, soy and isoflavone preparations, and body-mind therapies for managing symptoms of hot flashes and at least one additional symptom, including mood, sleep, pain, and cognitive symptoms.
Methods: Searched PubMED/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for randomized controlled trials reported in English between 2004 and 2012. Of 1193 abstracts identified, 59 trials included data on hot flash and at least one other symptom.
Results: Several trials of acupuncture (13), herbals including black cohosh (18), soy and isoflavone preparations (17), and body-mind therapies (9) yielded significant effects on multiple symptoms. Seven acupuncture trials revealed significantly reduced hot flash frequency, intensity or bother, along with improved mood and sleep. Chinese herbal medicine significantly reduced HF frequency, and mood, sleep, and pain. Four of 9 black cohosh trials significantly improved hot flashes, sleep and mood. Two trials of at least 60-70 mg of isoflavones daily significantly reduced vasomotor, sleep, cognitive and pain symptoms. Equol supplements of 30 mg/d for non-Equol producing women significantly reduced vasomotor, psychological and somatic symptoms. Two trials of Genistein preparations reduced hot flashes by 30-51% but not other symptoms. Red Clover isoflavone (80 mg/d) significantly reduced hot flashes, night sweats, sleep, cognition and pain symptoms. Mindfulness and relaxation therapy significantly reduced hot flashes and sleep symptoms. Yoga significantly reduced hot flashes and improved cognitive symptoms. Exercise trials yielded mixed results, with half significantly reducing hot flashes and one cognitive symptoms.
Conclusion: Few investigators report treatment effects in ways that allow clinicians to consider symptom clusters when prescribing therapies, despite promising therapies