Genome-wide blood DNA methylation profiles for cognitive declines among professional fighters

Abstract

Cognitive decline variabilities after head injuries may be regulated by altered DNA methylation. We successfully profiled genome-wide blood DNA methylation associated with cognitive declines among professional fighters. Our key network findings confirmed the effect of axonal dysfunction, altered dopamine feedback in cAMP signaling, altered methylation of BDNF promoters on cognition.

Authors

Hyunhwa Lee
Jacob White
Sijung Yun
Jonica Estrada
Laura Salado
Charles Bernick

Author Details

Hyunhwa Lee, PhD, APRN, PMHNP-BC, School of Nursing, University of Nevada, Las Vegas, Las Vegas, Nevada, USA; Jacob White, MS, College of Liberal Arts, University of Nevada Las Vegas, Las Vegas, Nevada, USA; Sijung Yun, PhD, Yotta Biomed, LLC., Bethesda, Maryland, USA; Jonica Estrada, BS, School of Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA; Laura Salado, BS, College of Arts, Sciences, and Education, Florida International University, Miami, Florida, USA; Charles Bernick, MD, PhD, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA

Sigma Membership

Zeta Kappa at-Large

Lead Author Affiliation

University of Nevada, Las Vegas, Las Vegas, Nevada, USA

Type

Presentation

Format Type

Text-based Document

Study Design/Type

N/A

Research Approach

N/A

Keywords:

Cognitive Decline, Head Trauma, Methylation

Recommended Citation

Lee, Hyunhwa; White, Jacob; Yun, Sijung; Estrada, Jonica; Salado, Laura; and Bernick, Charles, "Genome-wide blood DNA methylation profiles for cognitive declines among professional fighters" (2019). INRC (Congress). 332.
https://www.sigmarepository.org/inrc/2019/presentations_2019/332

Conference Name

30th International Nursing Research Congress

Conference Host

Sigma Theta Tau International

Conference Location

Calgary, Alberta, Canada

Conference Year

2019

Rights Holder

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Acquisition

Proxy-submission