Abstract

Patients undergoing total knee arthroplasty (TKA) present unique challenges for healthcare providers. With these procedures, blood loss is a major complication that can lead to anemia, delayed wound healing, joint contractures, and increased infection risk. The intra-operative administration of tranexamic acid (TXA) via peri-articular, intra-articular, or intravenous (IV) routes can lead to reduced blood loss and diminished transfusion requirements for patients post-operatively. The IV administration route only allows a small portion of the agent to reach the target tissue. In addition, the systemic effects and increased risk of venous thromboembolism associated with intravenous TXA can cause concern for specific patient populations. The peri-articular and intra-articular approaches to TXA administration have recently been adopted as an alternative to IV TXA. These administration routes result in diminished systemic absorption while still achieving a reduction in blood loss and post-operative transfusion requirements.

Author Details

Christopher Ryan Lonis, RN, BSN, SRNA

Sigma Membership

Theta Tau

Lead Author Affiliation

Samford University, Birmingham, Alabama, USA

Type

DNP Capstone Project

Format Type

Text-based Document

Study Design/Type

Literature Review

Research Approach

Translational Research/Evidence-based Practice

Keywords:

Tranexamic Acid, Total Knee Arthroplasty, Surgical Blood Loss, Transfusion Requirements

Advisor

Ledbetter, Maria

Degree

DNP

Degree Grantor

Samford University

Degree Year

2023

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.

All permission requests should be directed accordingly and not to the Sigma Repository.

All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Self-submission

Date of Issue

2023-02-28

Full Text of Presentation

wf_yes

Download

Additional Files

download (1910 kB)

Share

COinS