Perioperative Pharmacogenomic Utility and Personalized Anesthesia

Abstract

Genetic factors play a significant role in influencing drug response by encoding for the cellular targets of drugs and the enzymes responsible for terminating their effects. Genetic anomalies can lead to unpredictable responses and adverse drug reactions (ADRs), which can be challenging to foresee. Medication dosages are traditionally determined using population-based data which is a poor predictor of individual response. Resulting ADRs can surprise anesthetists and negatively influence patient outcomes. Pharmacogenomics (PGx) is emerging as a promising field to address this variability by mapping the relationship between genes and drug response, supporting the development of personalized anesthesia. As the cost of genome sequencing decreases, routine PGx incorporation becomes more feasible, and offers the potential to enhance care...

Authors

Anthony TortomaseFollow

Author Details

Anthony Tortomase, DNP(c), BSN. Anthony is currently pursuing his DNP in nurse anesthesia at Samford University in Birmingham, AL. He gained critical care experience working in the trauma & burn intensive care unit at UAB Hospital. In addition to his nursing education, he also obtained a Bachelor's of Science in Cellular and Molecular Biology from Auburn University.

Sigma Membership

Non-member

Type

DNP Capstone Project

Format Type

Text-based Document

Study Design/Type

Case Study/Series

Research Approach

Translational Research/Evidence-based Practice

Keywords:

Pharmacogenomics, Genetic Testing, Personalized Anesthesia

Advisor

Maria Ledbetter

Degree

DNP

Degree Grantor

Samford University

Degree Year

2025

Recommended Citation

Tortomase, Anthony, "Perioperative Pharmacogenomic Utility and Personalized Anesthesia" (2025). Group: Samford University Moffett & Sanders School of Nursing. 202.
https://www.sigmarepository.org/samford/202

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record. All permission requests should be directed accordingly and not to the Sigma Repository. All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Proxy-submission

Full Text of Presentation

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