Abstract

Remifentanil is an opioid analgesic that is administered intraoperatively via intravenous infusion to provide pain relief during surgery, particularly when using a total intravenous anesthetic approach. While it is desirable for its short half-life and potent analgesic properties, remifentanil has also been associated with acute opioid tolerance and increased opioid consumption postoperatively, a phenomenon known as opioid-induced hyperalgesia (OIH).1 Several pharmacological interventions have been suggested to prevent this occurrence, including the use of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist.1-2 In adults undergoing general anesthesia with a remifentanil infusion, does intraoperative administration of ketamine reduce the postoperative occurrence of OIH?

Author Details

Madeline Tisdale, BSN

Sigma Membership

Non-member

Lead Author Affiliation

Samford University, Birmingham, Alabama, USA

Type

DNP Capstone Project

Format Type

Text-based Document

Study Design/Type

Case Study/Series

Research Approach

Translational Research/Evidence-based Practice

Keywords:

Remifentanil, Hyperalgesia, Ketamine

Advisor

Cahoon, Terri

Degree

DNP

Degree Grantor

Samford University

Degree Year

2024

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.

All permission requests should be directed accordingly and not to the Sigma Repository.

All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Self-submission

Date of Issue

2024-01-17

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